Glucosamine Sulfate and Arthritis

March 11, 2010

Think you can’t do anything about your arthritis? Think again. A natural substance has been shown to be effective in decreasing pain and improving joint structure.

Osteoarthritis affects approximately 21 million adults in the United States. Also referred to as degenerative joint disease (DJD), osteoarthritis is believed to be the cumulative effect of decades of joint use. Over time, cartilage (connective tissue that cushions bones) deteriorates leaving pain and joint damage.

A naturally occurring substance, glucosamine, has been shown in clinical trials to be effective in relieving pain and inflammation of osteoarthritis.

Glucosamine is a key compound of the ground substance that comprises connective tissue. It is this ground substance, called proteoglycans, which determines the strength and resiliency of connective tissue.

The main action of glucosamine on joints is to provide the substances necessary for repair. Glucosamine is the preferred substrate and stimulant for proteoglycan synthesis and, at the same time, has a protective effect against joint destruction.

Conventional treatment for osteoarthritis includes aspirin or NSAIDS (non-steroidal anti-inflammatory drugs), such as ibuprofen. Some research has indicated that current drug therapy for osteoarthritis may be producing short-term benefit but actually inhibiting cartilage repair and accelerating cartilage destruction. There are also significant side effects to the medications.

Glucosamine is available as a supplement in several forms. The preferred and most researched form is glucosamine sulfate. Glucosamine stabilized by potassium chloride (KCl) vs. sodium chloride (NaCl) gives the same benefit without the added sodium.

You won’t find significant amounts of glucosamine in foods. Supplemental sources are from seashells.

Typical dosage is 500 mg, three times a day, away from meals. Therapy costs ranges from $25-$60 a month, depending on manufacturer and retail outlet. Buy from a well-known, well-established company to insure highest quality.

Glucosamine is generally well tolerated. A mild side effect may be reversible gastrointestinal upset. There has been some speculation to it contributing to insulin resistance. Therefore, diabetics should consult with their doctors before taking glucosamine and monitor blood sugar levels carefully if they decide to take it.

Glucosamine is a classic example of how a natural product improves a condition by addressing the underlying cause and supports the body’s ability to heal itself.

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